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NADH is a molecule that is produced naturally by the body. It functions as a coenzyme and helps with many chemical reactions in the body. As a supplement, it supposedly helps treat a wide range of conditions, from depression to jet lag to high cholesterol. However, there is no scientific evidence supporting the effectiveness of this supplement for these uses.

What Is NADH?

NADH (nicotinamide adenine dinucleotide hydrate) is a naturally occurring molecule found throughout the human body. It is not considered a vitamin, since the body can make its own NADH. It is also used as an ingredient in dietary supplements and has been claimed to help with the following conditions:
These are just some of the reported uses. NADH is often promoted as a supplement for general health and nutritional enhancement.
(Click NADH Benefits for more information.)

How Does It Work?

NADH is a molecule that works as a coenzyme in the human body. Coenzymes help other enzymes work in chemical reactions. Many essential chemical reactions in the body use NADH. It is not known exactly how supplementation could work for various conditions, especially since the body can make its own. NADH may have antioxidant activity, and this may be one way that it works for various conditions.

Is NADH Effective?

At this time, there is not enough scientific evidence available to suggest that NADH is truly effective for any use (see Does NADH Work?).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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