Phosphatidylserine

Phosphatidylserine is a molecule that is important for normal brain function. It is made by the human body and is found in many foods, but is also often used in dietary supplements. These supplements are claimed to be beneficial for conditions such as Alzheimer's disease, ADHD, depression, and age-related dementia. Potential side effects of phosphatidylserine supplements include insomnia, gas, and upset stomach.

What Is Phosphatidylserine?

Phosphatidylserine is a naturally occurring molecule found throughout the human body. Although the body can make its own, most of this nutrient is obtained through the diet. It is also used in dietary supplements, sometimes claimed to be helpful for the following uses:
 
(Click Phosphatidylserine Benefits for more information, including additional uses for the supplement.)
 

How Does It Work?

Phosphatidylserine is a phospholipid, a molecule that is used in cell membranes in the human body. It is abundant in the human brain and is important for a variety of different functions and processes within it.
 
It is not known exactly how phosphatidylserine supplementation works for Alzheimer's disease or other uses, although it is thought that levels may decline with age and with certain medical conditions, such as Alzheimer's.
 

Is Phosphatidylserine Effective?

At this time, early inconclusive evidence suggests that phosphatidylserine may work for Alzheimer's disease and may improve age-related problems in mental functioning, such as memory problems.
 There is not enough evidence to rate the effectiveness of this supplement for other uses.
 
(Click Does Phosphatidylserine Work? for more information.)
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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