Phosphatidylserine Side Effects

Insomnia, upset stomach, and gas are some of the side effects that have been reported with phosphatidylserine. Side effects of the supplement are fairly minor and are generally related to the dosage, as they are more common with higher doses. Serious phosphatidylserine side effects have not been reported, but allergic reactions are possible (as with any medication or supplement).

 

Does Phosphatidylserine Cause Side Effects?

As with any medication or supplement, side effects are possible with phosphatidylserine. Often, people assume that natural products (such as phosphatidylserine) are automatically free of side effects. However, this is simply not the case.
 

Reported Phosphatidylserine Side Effects

In general, reported phosphatidylserine side effects are fairly minor and are related to the dose (with side effects being more common with higher dosages). Some of the reported phosphatidylserine side effects include:
 

Side Effects With Phosphatidylserine to Report

Serious side effects have not been reported with phosphatidylserine. Of course, allergic reactions to any supplement or medication may be possible. Be sure to watch for any signs of an allergic reaction, such as a rash, hives, itching, swelling of the mouth or throat, wheezing, or difficulty breathing.
 
If you use an animal-based phosphatidylserine product, it is theoretically possible that such supplements could cause problems. Some older phosphatidylserine supplements were made using brain material from cows. However, due to concerns that such supplements could cause problems (such as mad cow disease), most manufacturers have switched to phosphatidylserine made from soy lecithin (a plant-based source).
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;