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Safety Concerns With Phosphatidylserine

Specific Phosphatidylserine Warnings and Precautions

Warnings and precautions to be aware of concerning the safety of phosphatidylserine include the following:
  • Check with your healthcare provider before taking phosphatidylserine (or any other dietary supplement) if you have any chronic or serious medical conditions.
  • Supplements (including phosphatidylserine) are not regulated as closely as drugs. In fact, supplements can be sold in the United States without ever having been shown to be safe or effective.
  • If you have liver or kidney disease, check with your healthcare provider before taking any medication or supplement, including phosphatidylserine. Many medications and supplements are cleared from the body using the liver and kidneys.
  • Phosphatidylserine supplements can potentially interact with some medications (see Phosphatidylserine Drug Interactions for more information).
  • It is not known whether phosphatidylserine supplements are safe for pregnant or breastfeeding women (see Phosphatidylserine and Pregnancy and Phosphatidylserine and Breastfeeding).
  • If you decide to use supplements, be aware that what you see on the label may not reflect what is in the bottle. For example, some dietary supplements have been found to be contaminated with heavy metals or prescription drugs, and some have been found to have much more or much less of the featured ingredient than their label states. Therefore, make sure the manufacturer of your phosphatidylserine product is a trusted and reputable manufacturer. It is a good sign if a manufacturer abides by the rules of Good Manufacturing Practices (GMP) for drugs. It is also a good sign if a product has the United States Pharmacopoeia (USP) seal, which means that the product has been independently tested and shown to contain the correct ingredients in the amounts listed on the label. Your pharmacist is a good resource for information about which manufacturers are most reputable.
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