Aricept Drug Interactions

If certain medicines, such as ketoconazole or general anesthetics, are taken together with Aricept, drug interactions may potentially occur. While some interactions can decrease the effectiveness of the drugs, others can increase the risk of developing serious side effects or complications. Other drugs that can potentially interact with Aricept may include other cholinesterase inhibitors, anticholinergic medicines, succinylcholine, and St. John's wort.

 

Aricept Drug Interactions: An Introduction

Aricept® (donepezil hydrochloride) has the potential to interact with a number of other medications. Some of these Aricept drug interactions include:
 
  • Other cholinesterase inhibitors, including:

 

 

  • Bethanechol (Urecholine®)
     
  • Succinylcholine (Quelicin®)
     
  • General anesthetics
     
  • Anticholinergic medicines, including:

 

 

  • Ketoconazole (Nizoral®)
     
  • SSRI-type anti-depressants, including:

 

 

  • Barbiturates, including:

 

    • Amobarbital (Amytal®)
    • Butabarbital (Butisol Sodium®)
    • Phenobarbital (Luminal®)
    • Primidone (Mysoline®)
    • Pentobarbital (Nembutal®)
    • Thiopental (Pentothal®)

 

  • Certain anticonvulsants, including:

 

 

  • Rifamycin antibiotics, including:

 

    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
    • Rifapentine (Priftin®)

 

 

(Aricept Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;