Does Acetyl-L-Carnitine Work?

Acetyl-L-carnitine supplements are supposedly useful for a number of conditions, but does acetyl-L-carnitine work? Studies have shown that the supplements may be effective in treating several conditions, such as improving cognitive functioning and memory in people with age-related memory problems, alcoholism, or Alzheimer's disease. However, more research is needed to confirm whether acetyl-L-carnitine really works for these and other uses.

Does Acetyl-L-Carnitine Really Work?

As with most dietary supplements, acetyl-L-carnitine is claimed to work for a variety of different uses. But does it really work? This article will address the effectiveness of acetyl-L-carnitine for various uses, including treatment of the following conditions:
 

Scientific Evidence Supporting Acetyl-L-Carnitine Use

Preliminary evidence suggests that acetyl-L-carnitine may actually be beneficial for improving cognitive function and memory in people with age-related memory problems, alcoholism, or Alzheimer's disease. Research also suggests that the supplement may help improve symptoms of age-related testosterone decreases in men. Improvements were seen in sexual dysfunction, depression, and fatigue in men with "male menopause."
 
Acetyl-L-carnitine appears to improve the symptoms of nerve pain due to diabetes. When combined with L-carnitine (a similar product), acetyl-L-carnitine improved sperm count and sperm motility in men with infertility. The supplement may also help relieve pain and delay the worsening of Peyronie's disease. A single dose of IV acetyl-L-carnitine has been shown to improve blood flow in the brain in people with chronic poor circulation to the brain, although it is unknown if oral supplementation or long-term supplementation will produce similar results.
 
At this time, there is not enough scientific evidence to suggest that acetyl-L-carnitine really works or does not work for other uses.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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