Acetyl-L-Carnitine

Acetyl-L-carnitine is a compound that is found naturally in the human body. This compound is also available in dietary supplements and is claimed to have several medicinal uses. Although this supplement is generally considered safe for most people, make sure to talk to your healthcare provider about any other medical conditions you may have or any other medications you are taking before using it.

What Is Acetyl-L-Carnitine?

Acetyl-L-carnitine is a naturally occurring compound found throughout the human body. It can be obtained through the diet (from red meat and dairy), although the body can also make the compound using amino acids. Acetyl-L-carnitine is also available in dietary supplements, which are claimed to be useful for treating a number of different medical conditions.
 
(Click Benefits of Acetyl-L-Carnitine for more information about possible uses.)
 

How Does It Work?

Acetyl-L-carnitine is essential for proper functioning of mitochondria, the "energy factories" of human cells. For most people, the body can make plenty of this compound on its own, making supplementation unnecessary. However, for some individuals (such as premature infants or people with certain genetic defects), supplementation with some form of carnitine (such as acetyl-L-carnitine) is necessary. In critical situations, the use of the prescription product levocarnitine (Carnitor®) is usually preferred.
 
It is not entirely clear exactly how this compound works for the various conditions for which it is used, although different mechanisms have been suggested by researchers.
 

Is Acetyl-L-Carnitine Effective?

Preliminary research suggests that this supplement might be effective for a number of different uses, although more research is necessary to confirm these early findings (see Does Acetyl-L-Carnitine Work? for more information).
 

Dosing Information

As with most dietary supplements, there is no well-established standard dosage for acetyl-L-carnitine, although some information can be obtained from clinical trials that used the supplement.
 
(Click Acetyl-L-Carnitine Dosage for more information.)
 

Are There Side Effects?

Even though it is a "natural" product, acetyl-L-carnitine can cause side effects. In general, however, the supplement is well tolerated, especially if used appropriately.
 
(Click Acetyl-L-Carnitine Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
 

Drug Interactions

Acetyl-L-carnitine may interact with at least one medication (see Acetyl-L-Carnitine Drug Interactions).
 

Safety Issues With Acetyl-L-Carnitine

This supplement is generally considered safe for many people, especially when used appropriately. However, some people may be more likely to experience problems with it than others. Therefore, you should talk with your healthcare provider prior to taking acetyl-L-carnitine if you have:
 
  • An underactive thyroid (hypothyroidism)
  • Seizures or epilepsy
  • Any chronic medical condition
  • Any allergies, including allergies to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and nonprescription medications, vitamins, and herbal supplements.
 
(Click Is Acetyl-L-Carnitine Safe? for more information, including any available warnings and precautions.)
 

What If I Take an Overdose?

It is not clear what exactly to expect from an overdose with this supplement. If you think you or someone else may have taken too much acetyl-L-carnitine, it is important to seek immediate medical attention.
 
(Click Acetyl-L-Carnitine Overdose for more information.)
 

How Should Acetyl-L-Carnitine Be Stored?

Refer to the label of your individual product for information on how best to store it. Keep all medications and supplements out of the reach of children.
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
Other Articles in This eMedTV Presentation